SecureCattle:
The FIRST and Most Studied BAP
Based on 30+ years of research and development by the scientists at IRSEA/Signs Labs in France, you can have confidence that every dose will make a difference to the wellbeing of your cattle. SecureCattle has shown benefit when used in cattle of all ages and stages to alleviate stress and improve well-being. Below are the extensive peer-reviewed studies using SecureCattle conducted by the IRSEA/SIGNS group and their partners.
Research in Dairy
SecureCattle has been studied extensively in both cows and calves prior to stressful events. Below is an outline of the research
Effects of administering an appeasing substance to Gir x Holstein female calves on pre-weaning performance and disease incidence.
Reducing stress in young calves helps them grow better and stay on track, even when they face common challenges like scours or pneumonia. In this study, calves given an appeasing substance were heavier at weaning and needed fewer treatment costs, even though disease rates stayed similar. Bottom line: less stress means better performance and lower treatment costs—simple as that.
Effects of a synthetic analog of the bovine appeasing pheromone on the overall welfare of dairy calves from birth through weaning
Calves face real stress at weaning, and that stress can slow growth and disrupt normal behavior. Using an appeasing pheromone helped calves cope better—supporting higher weight gains after weaning and reducing signs of stress like elevated cortisol and restlessness. Bottom line: calmer calves handle weaning better, grow more efficiently, and stay on track.
The effects of a synthetic analogue of the bovine appeasing pheromone on milk yield and composition in dairy cows during management transition
When cows go through stressful changes like turnout or regrouping, performance often takes a hit. Using an appeasing pheromone helped cows adapt better—leading to higher milk production and lower somatic cell counts during that transition. Bottom line: smoother adaptation means better milk and healthier cows.
Effect of bovine appeasing substance on multiparous Holstein cows during the transition period.
Cows around calving are under a lot of stress, and that stress can limit milk production and efficiency. In this study, cows given an appeasing substance produced about 3 kg more milk per day, had lower stress (cortisol), and converted feed more efficiently despite eating less. Bottom line: calmer transition cows milk harder, use feed better, and stay more metabolically stable.
Research in Beef
SecureCattle has been studied extensively in beef calves prior to stressful events. Below is an outline of the research
Administering an appeasing substance to optimize performance and health responses in feedlot receiving cattle
Feedlot entry is a high-stress period, and that stress can drag down performance and health. In this study, cattle given an appeasing substance gained weight faster and converted feed more efficiently, without eating more . Bottom line: reduce stress at arrival, and cattle grow better and use feed more effectively.
Short communication: administering an appeasing substance to Bos
indicus-influenced beef cattle at weaning and feedlot entry
Weaning and feedlot entry are major stress points that can slow growth and hurt performance. In this study, calves given an appeasing substance grew faster after weaning and showed reduced inflammation linked to stress. Bottom line: reducing stress at key events helps cattle stay healthier and keep gaining.
Short communication: Administration of an appeasing substance to Bos
indicus-influenced beef cattle improves performance after weaning and
carcass pH
Stress at weaning and transport hurts growth and meat quality. Calves given an appeasing substance gained faster and had better carcass outcomes. Bottom line: less stress = better performance and value.
Administering an appeasing substance to beef
calves at weaning to optimize productive and health
responses during a 42-d preconditioning program
Weaning stress impacts growth, behavior, and immunity in calves. In this study, calves given an appeasing substance showed lower stress, better early growth, and stronger vaccine response. Bottom line: reducing stress helps calves adapt faster and stay healthier.
Strategic administration of an appeasing substance
to improve performance and physiological responses
of Bos indicus feedlot cattle
Giving an appeasing substance before transport helped feedlot cattle eat more, gain faster, and finish heavier, with benefits lasting the entire feeding period. Bottom line: reduce stress early, and you improve both performance and carcass value.
Appeasing Pheromones against Bovine Respiratory Complex
and Modulation of Immune Transcript Expressions
Appeasing pheromones didn’t improve overall weight gain but shifted disease patterns—more early respiratory signs, followed by fewer cases later in the feeding period. This likely reflects an immune modulation effect, with increased IL-8 expression suggesting a stronger early immune response and faster recovery from infection
Effects of an Appeasing Substance Application atWeaning on
Growth, Stress, Behavior, and Response to Vaccination of
Bos indicus Calves
Bovine appeasing substance given at weaning reduced stress (lower cortisol and improved temperament), leading to better early behavior (more grazing, less vocalization) and a short-term improvement in weight gain. It also enhanced vaccine response (notably PI3 and BVDV-1), suggesting improved immune function during the immediate post-weaning period
Use of Restricted Nursing and a Bovine Appeasing
Substance on the Welfare, Growth Performance, and
Response to Vaccination of Beef Calves at Weaning
Bovine appeasing substance reduced weaning stress (improved temperament and behavior), which translated into better early growth performance compared to controls. It also enhanced vaccine response, with higher antibody titers post-weaning, suggesting improved immune function during this critical period
Appeasing Substance Administration at Feedlot Entry Impacted Temperament, Pen Behavior, Immunocompetence, and Meat Quality of Beef Heifers
Bovine appeasing substance reduced stress (lower cortisol and inflammation), improved behavior and adaptation, and increased early growth performance in feedlot heifers. It also enhanced immune response to vaccination, with higher antibody titers following respiratory vaccination
Multiple administrations of bovine-appeasing substance during a 42-d preconditioning program followed by feedlot receiving and its effects on physiologic, health, and performance responses of feeder cattle
Multiple administrations of bovine appeasing substance reduced stress responses—evidenced by lower haptoglobin, NEFA, and exit velocity—indicating improved adaptation to weaning and handling challenges. However, these physiological and behavioral benefits did not translate into improved growth performance during preconditioning or feedlot receiving